Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-kB-dependent Signaling Pathway02:26

NF-kB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimal clinicogenetic criteria for post-operative re-irradiation in recurrent glioblastoma: KROG 21-02.

ESMO open·2026
Same author

Generation of a quasi-Bessel beam with a super-Gaussian axial intensity profile.

Applied optics·2026
Same author

Accuracy of artificial intelligence-assisted growth prediction in skeletal Class I preadolescent patients using serial lateral cephalograms for a 2-year growth interval.

Orthodontics & craniofacial research·2024
Same author

Adrenalectomy for the treatment of hypotension in a cat with phaeochromocytoma associated with caudal vena cava syndrome.

The Journal of small animal practice·2024
Same author

Health-related quality of life in patients with generalized pustular psoriasis: A systematic literature review.

Journal of the European Academy of Dermatology and Venereology : JEADV·2023
Same author

OsCM regulates rice defence system in response to UV light supplemented with drought stress.

Plant biology (Stuttgart, Germany)·2023

Related Experiment Video

Updated: May 16, 2026

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells
10:57

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells

Published on: January 12, 2020

NF-κB: an essential transcription factor in psoriasis.

A M Goldminz1, S C Au, N Kim

  • 1Department of Dermatology, Tufts Medical Center, Boston, MA 02111, USA. ari.goldminz@gmail.com

Journal of Dermatological Science
|December 11, 2012
PubMed
Summary

Nuclear factor kappa B (NF-κB) is central to psoriasis pathogenesis. Targeting this pathway offers therapeutic potential but requires balancing efficacy with risks like immunodeficiency.

More Related Videos

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
11:27

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

Published on: November 2, 2018

Related Experiment Videos

Last Updated: May 16, 2026

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells
10:57

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells

Published on: January 12, 2020

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
11:27

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

Published on: November 2, 2018

Area of Science:

  • Immunology
  • Dermatology
  • Molecular Biology

Background:

  • Nuclear factor kappa B (NF-κB) is a critical transcription factor regulating inflammation, immunity, cell proliferation, and apoptosis.
  • NF-κB plays a significant role in the pathogenesis of psoriasis, an inflammatory skin condition characterized by elevated active NF-κB levels.

Purpose of the Study:

  • To explore the role of NF-κB in psoriasis pathogenesis.
  • To investigate NF-κB as a therapeutic target for psoriasis and other inflammatory disorders.

Main Methods:

  • Review of genomic studies linking psoriasis to NF-κB pathway mediators.
  • Analysis of current and developing anti-psoriatic therapies targeting NF-κB.
  • Discussion of potential strategies for safe and effective NF-κB inhibition.

Main Results:

  • NF-κB is hypothesized to link altered keratinocyte and immune cell behavior in psoriasis.
  • Existing therapies like TNF-α blockers and glucocorticoids reduce active NF-κB.
  • Emerging biologics, such as IL-17 blockers, may also target the NF-κB pathway.

Conclusions:

  • Targeting NF-κB signaling presents a novel therapeutic avenue for psoriasis and chronic inflammatory diseases.
  • Chronic NF-κB inhibition carries risks, including potential immunodeficiencies.
  • Therapeutic strategies must balance efficacy with safety, possibly through localized therapy, selective inhibition, or dose/duration adjustments.