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The Bioconjugation and Radiosynthesis of 89Zr-DFO-labeled Antibodies
Published on: February 12, 2015
High specific activity ⁶¹Cu via ⁶⁴Zn(p,α)⁶¹Cu reaction at low proton energies
Stefan Thieme1, Martin Walther, Stephan Preusche
1Institute of Radiopharmacy, Helmholtz-Zentrum Dresden-Rossendorf, P.O. Box 510 119, 01314 Dresden, Germany.
Abstract:
The PET radionuclide (61)Cu is accessible through several nuclear reactions. Besides the common production route via (61)Ni(p,n)(61)Cu the (64)Zn(p,α)(61)Cu reaction offers some advantages. Especially the comparatively cheap enriched (64)Zn makes this process economical. For fast product purification and recycling of target material an ion exchange cascade was developed. In addition a separation technique with a copper selective resin was tested. (61)Cu with specific activities up to 1000 GBq/μmol was produced with these methods.
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