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Updated: May 16, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Circulating humanin levels are associated with preserved coronary endothelial function.

R J Widmer¹, A J Flammer, J Herrmann

¹Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and College of Medicine, Rochester, Minnesota 55905, USA.

American Journal of Physiology. Heart and Circulatory Physiology

|December 11, 2012

Summary

Patients with coronary endothelial dysfunction have lower systemic humanin levels. Higher humanin levels correlate with improved coronary blood flow, suggesting a potential diagnostic and therapeutic role for humanin in cardiovascular health.

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A Novel In vitro Model for Studying the Interactions Between Human Whole Blood and Endothelium

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A Novel In vitro Model for Studying the Interactions Between Human Whole Blood and Endothelium

A Novel In vitro Model for Studying the Interactions Between Human Whole Blood and Endothelium

Published on: November 21, 2014

Area of Science:

Cardiovascular Research
Endocrinology
Molecular Biology

Background:

Humanin is an antiapoptotic peptide found in endothelium and atherosclerotic plaques.
Endothelial dysfunction precedes atherosclerotic plaque development, creating a pro-inflammatory and apoptotic environment.
Previous animal studies suggest humanin administration may enhance endothelial function.

Purpose of the Study:

To investigate the hypothesis that patients with coronary endothelial dysfunction exhibit reduced systemic humanin levels.
To explore the association between humanin levels and coronary endothelial function in patients undergoing angiography.

Main Methods:

Forty patients undergoing coronary angiography and endothelial function testing were divided into two groups based on coronary blood flow (CBF) response to acetylcholine.
Aortic plasma samples were analyzed for humanin levels and traditional atherosclerosis biomarkers.
Coronary blood flow changes were measured to assess endothelial function.

Main Results:

Patients with coronary endothelial dysfunction showed significantly lower humanin levels (1.3 ± 1.1 ng/ml) compared to those with normal function (2.2 ± 1.5 ng/ml).
A significant positive correlation was observed between improved CBF and humanin levels (P = 0.0091).
No association was found between humanin levels and C-reactive protein, Lp-Pla(2), or homocysteine.

Conclusions:

Preserved human coronary endothelial function is uniquely associated with higher systemic humanin levels.
Humanin may serve as a potential diagnostic biomarker for coronary endothelial dysfunction.
Humanin presents a potential therapeutic target for improving endothelial function in cardiovascular disease.