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Related Experiment Video

Updated: May 16, 2026

Isolation and Culture of Cells from the Nephrogenic Zone of the Embryonic Mouse Kidney
08:06

Isolation and Culture of Cells from the Nephrogenic Zone of the Embryonic Mouse Kidney

Published on: April 22, 2011

Comprehensive gene expression changes associated with mouse postnatal kidney development.

Bo Wu1, Debashis Sahoo, James D Brooks

  • 1Department of Urology and Stanford Institute for Stem Cell Biology and Regenerative Medicine (DS), Stanford University, Stanford, California 94305-5118, USA.

The Journal of Urology
|December 11, 2012
PubMed
Summary
This summary is machine-generated.

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This study maps molecular changes during mouse kidney development. Gene expression profiling reveals dynamic shifts in pathways related to cell growth, metabolism, and tissue development in the first five weeks of life.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genomics

Background:

  • Postnatal kidney development involves complex molecular processes.
  • Understanding these changes is crucial for interpreting kidney diseases.

Purpose of the Study:

  • To profile molecular alterations in mouse renal growth during the first five weeks of postnatal life.
  • To create a comprehensive temporal survey of gene expression during kidney development.

Main Methods:

  • Kidneys from C57BL/6 mice were analyzed at multiple postnatal time points.
  • Gene expression profiling was performed using microarrays.
  • Transcripts and biological functions were identified using StepMiner and IPA® software.

Main Results:

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Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment
06:48

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Published on: April 29, 2022

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Last Updated: May 16, 2026

Isolation and Culture of Cells from the Nephrogenic Zone of the Embryonic Mouse Kidney
08:06

Isolation and Culture of Cells from the Nephrogenic Zone of the Embryonic Mouse Kidney

Published on: April 22, 2011

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment
06:48

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Published on: April 29, 2022

  • Widespread gene expression changes occurred, with thousands of transcripts up- and down-regulated.
  • Early postnatal development showed down-regulation of cell growth pathways.
  • Later stages revealed shifts towards metabolism, transport, and down-regulation of cell cycle and tissue development genes.

Conclusions:

  • This study provides the most comprehensive temporal gene expression dataset for postnatal kidney development.
  • The data serves as a framework for understanding kidney pathologies, including congenital obstruction-induced nephropathy.