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Related Concept Videos

Lampbrush Chromosomes01:51

Lampbrush Chromosomes

In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops resemble the...
Lampbrush Chromosomes01:51

Lampbrush Chromosomes

In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops resemble the...
Chromosome Structure02:40

Chromosome Structure

A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
Chromosome Structure02:40

Chromosome Structure

A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
Polytene Chromosomes02:04

Polytene Chromosomes

Polytene chromosomes are giant interphase chromosomes with several DNA strands placed side by side. They were discovered in the year 1881 by Balbiani in salivary glands, intestine, muscles, malpighian tubules, and hypoderm of larvae Chironomus plumosus. Hence, these are also called "Salivary gland chromosomes." These are found in insects of the order Diptera and Collembola; in certain organs of mammals; and synergids, antipodes of flowering plants. Polytene chromosomes are also regularly...
Polytene Chromosomes02:04

Polytene Chromosomes

Polytene chromosomes are giant interphase chromosomes with several DNA strands placed side by side. They were discovered in the year 1881 by Balbiani in salivary glands, intestine, muscles, malpighian tubules, and hypoderm of larvae Chironomus plumosus. Hence, these are also called "Salivary gland chromosomes." These are found in insects of the order Diptera and Collembola; in certain organs of mammals; and synergids, antipodes of flowering plants. Polytene chromosomes are also regularly...

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Updated: May 16, 2026

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay
06:25

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay

Published on: February 6, 2012

ChromoZoom: a flexible, fluid, web-based genome browser.

Theodore R Pak1, Frederick P Roth

  • 1Donnelly Centre, University of Toronto, Toronto, ON M5S3E1, Canada.

Bioinformatics (Oxford, England)
|December 11, 2012
PubMed
Summary
This summary is machine-generated.

ChromoZoom is a new web genome browser that enhances data exploration. It uses server-side rendering for general tracks and client-side rendering for custom data, improving performance and user experience.

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Last Updated: May 16, 2026

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay
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Published on: February 6, 2012

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An Integrated Approach for Microprotein Identification and Sequence Analysis

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Area of Science:

  • Bioinformatics
  • Genomics
  • Web Development

Background:

  • Current web-based genome browsers often require repetitive user input for navigation and data display.
  • Server-side or client-side processing limitations hinder efficient exploration of large genomic datasets.

Purpose of the Study:

  • To develop an interactive web interface for rapid and simultaneous exploration of genomic datasets.
  • To overcome the limitations of existing genome browsers by optimizing data processing and rendering.

Main Methods:

  • ChromoZoom pre-renders and caches common genomic tracks as tiled images on the server.
  • It employs an interactive web interface with inertial scrolling and smooth zooming capabilities.
  • Custom data tracks are rendered client-side, reducing server load and enhancing data privacy.

Main Results:

  • ChromoZoom enables fluent zooming and scrolling across multiple orders of magnitude.
  • It efficiently integrates curated, experimental, and personal genomic datasets.
  • Server load is minimized through a hybrid rendering approach.

Conclusions:

  • ChromoZoom provides a significantly improved user experience for genomic data exploration.
  • The tool facilitates rapid and simultaneous analysis of diverse genomic information.
  • It offers a scalable and efficient solution for visualizing complex genomic data.