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Oncogenic osteomalacia -- hypophosphataemic spectrum from "benignancy" to "malignancy"
1Department of Endocrinology, Singapore General Hospital, Outram Road, Singapore.
Bone
|December 11, 2012
Summary
Oncogenic osteomalacia (TIO) is a rare paraneoplastic syndrome causing severe hypophosphatemia and skeletal issues. Early recognition of TIO's diverse causes, from benign to malignant tumors, is crucial for timely diagnosis and treatment.
Area of Science:
- Endocrinology
- Oncology
- Rheumatology
Background:
- Oncogenic osteomalacia (TIO), a paraneoplastic syndrome, results in renal phosphate wasting and hypophosphatemia.
- While case reports exist, a comprehensive series detailing TIO causes from benign to malignant from a single institution is lacking.
Observation:
- This series presents three patients diagnosed with TIO between 2010-2012.
- Patient tumors varied, including a subcutaneous mesenchymal tumor, a nasal cavity connective tissue variant, and metastatic prostate cancer.
Findings:
- All patients exhibited severe hypophosphatemia and significant skeletal complications.
- Delayed diagnosis prolonged the metabolic and skeletal burden in affected individuals.
Implications:
- Timely recognition of TIO's clinical and biochemical features is critical for effective management.
- Physicians must be aware of TIO's presentation and diagnostic/treatment strategies for diverse underlying etiologies.
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