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Related Concept Videos

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: May 16, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Ophthalmoplegic migraine with persistent dilated pupil.

Inês Sobreira1, Cátia Sousa, Ana Raposo

  • 1Department of Pediatrics, Hospital do Divino Espírito Santo-EPE, Ponta Delgada, Azores, Portugal.

Journal of Child Neurology
|December 11, 2012
PubMed
Summary

Ophthalmoplegic migraine, a rare disorder, can cause persistent pupil dilation even after headaches resolve. This case highlights residual mydriasis in a young patient, underscoring the need for further research into its mechanisms.

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Area of Science:

  • Neurology
  • Ophthalmology

Background:

  • Ophthalmoplegic migraine is a rare neurological disorder presenting with recurrent ophthalmoplegia and migraine headaches, typically in childhood.
  • Cranial nerve III (oculomotor nerve) involvement is most frequent, while cranial nerves IV (trochlear) and VI (abducens) are less commonly affected.

Observation:

  • A 15-year-old female diagnosed with ophthalmoplegic migraine at age 9 experienced recurrent attacks.
  • Despite resolution of migraine episodes, she developed persistent right-eye mydriasis (abnormal dilation of the pupil).

Findings:

  • Pupillary involvement is common in pediatric ophthalmoplegic migraine, with most cases showing full recovery.
  • This case demonstrates a persistent residual mydriasis, a less common outcome, suggesting potential complications or distinct pathophysiological pathways.

Implications:

  • The underlying mechanisms of residual mydriasis in ophthalmoplegic migraine remain unclear, necessitating further investigation.
  • Potential associations with comorbidities like Adie tonic pupil warrant consideration in understanding long-term sequelae.