Related Experiment Video

Updated: May 16, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Mean platelet volume is increased in infective endocarditis and decreases after treatment

Atilla Icli1, Senol Tayyar, Ercan Varol

  • 1Department of Cardiology, Ahi Evran University Education and Research Hospital, Kirsehir, Turkey.

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
|December 11, 2012
PubMed
Abstract

Insights

Infective endocarditis patients show higher mean platelet volume (MPV), indicating increased platelet activation. Treatment for infective endocarditis significantly reduces MPV, decreasing this activation.

Area of Science:

  • Cardiology
  • Hematology
  • Infectious Diseases

Background:

  • Infective endocarditis is a serious infection affecting heart valves.
  • Platelet activation plays a role in the pathophysiology of infective endocarditis.

Purpose of the Study:

  • To evaluate mean platelet volume (MPV) as an indicator of platelet activation in infective endocarditis.
  • To assess the change in MPV following treatment for infective endocarditis.

Main Methods:

  • A comparative study involving 29 patients with infective endocarditis and 29 healthy controls.
  • Measurement of plasma MPV on admission and after two weeks of targeted treatment.

Main Results:

  • Patients with infective endocarditis exhibited significantly higher MPV compared to controls (9.86 ± 1.1 fl vs. 8.0 ± 1.0 fl, p < 0.01).
  • MPV levels in infective endocarditis patients decreased significantly post-treatment (9.86 ± 1.1 fl to 7.86 ± 1.0 fl, p < 0.01).
  • Total platelet counts increased significantly after treatment (193.4 ± 96.5 × 10(9) to 243.7 ± 92.4 × 10(9), p = 0.04).

Conclusions:

  • Elevated MPV in infective endocarditis suggests heightened platelet activation.
  • Successful treatment of infective endocarditis leads to a significant reduction in MPV, indicating decreased platelet activation.

More Related Videos

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice11:18

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

Published on: April 2, 2013

Intravital Microscopy of Leukocyte-endothelial and Platelet-leukocyte Interactions in Mesenterial Veins in Mice05:12

Intravital Microscopy of Leukocyte-endothelial and Platelet-leukocyte Interactions in Mesenterial Veins in Mice

Published on: August 13, 2015

Related Concept Videos

Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...