Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

Peripheral Artery Disease I: Introduction

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

Peripheral Artery Disease IV: Nursing Management

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...

Peripheral Artery Disease V: Postoperative Nursing Management

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Efficacy and clinical outcomes of catheter ablation for atrial arrhythmia in cardiac amyloidosis.

Heart rhythm·2024

Same author

Pericardial Decompression Syndrome: A Comprehensive Review of a Controversial Entity.

The International journal of angiology : official publication of the International College of Angiology, Inc·2024

Same author

Heteroleptic Magnesium <i>n</i>-Butyl on a Chemically Non-innocent 2-Anilidomethylpyridine Ligand Leading to Diverse Magnesium Hydrides.

Inorganic chemistry·2024

Same author

Sex Differences and Clinical Outcomes in Patients With Myocardial Infarction With Nonobstructive Coronary Arteries: A Meta-Analysis.

Journal of the American Heart Association·2024

Same author

Navigating Early Management Strategies in Acute Myocardial Infarction With Cardiogenic Shock.

The American journal of cardiology·2024

Same author

The Prevalence of Internet Use as a Source of Information Among Patients With Hypertension.

Cureus·2024

Search research articles

Related Experiment Video

Updated: May 16, 2026

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication

Published on: December 11, 2013

Peripheral arterial disease: implications beyond the peripheral circulation.

Kosmas I Paraskevas¹, Debabrata Mukherjee, Thomas F Whayne

¹1Vascular surgeon, Athens, Greece.

|December 11, 2012

Summary

Peripheral arterial disease (PAD) is often underdiagnosed and undertreated, despite being a significant indicator of widespread atherosclerosis. Early diagnosis and comprehensive management are crucial for reducing cardiovascular risks and improving patient outcomes.

Keywords:

cardiovascular disease generalized atherosclerosis peripheral arterial disease statins

More Related Videos

A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure

A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure

Published on: May 15, 2020

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Published on: June 2, 2019

Related Experiment Videos

Last Updated: May 16, 2026

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication

Published on: December 11, 2013

A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure

A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure

Published on: May 15, 2020

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Published on: June 2, 2019

Area of Science:

Vascular Medicine
Cardiovascular Disease Epidemiology

Background:

Peripheral arterial disease (PAD) affects a substantial population segment, often presenting with subclinical manifestations leading to underdiagnosis and undertreatment.
PAD signifies generalized vascular atherosclerosis, correlating with increased prevalence of coronary/carotid artery disease and abdominal aortic aneurysms.
PAD is also identified as a predictor for elevated risks of lung and other cancers.

Discussion:

The ankle-brachial pressure index (ABPI), a common diagnostic tool for PAD, also serves as a prognostic marker for systemic atherosclerosis, cardiovascular events, and mortality.
Biomarkers associated with PAD, such as C-reactive protein and serum bilirubin, may predict other comorbidities like kidney dysfunction.
Effective PAD management necessitates addressing the systemic atherosclerotic burden, not solely focusing on peripheral circulation.

Key Insights:

PAD is an underdiagnosed condition with significant systemic implications beyond peripheral arteries.
The ABPI is a valuable tool for assessing PAD and predicting broader cardiovascular and atherosclerotic risks.
Integrated patient management is essential to mitigate the systemic effects of PAD.

Outlook:

Further research into novel diagnostic markers and therapeutic strategies for PAD is warranted.
Enhanced screening protocols could improve early detection rates for PAD and associated systemic conditions.
A holistic approach to PAD management, encompassing systemic risk factor control, is crucial for long-term patient health.