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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Related Experiment Video

Updated: May 16, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Basal cell carcinoma with osteosarcomatous component.

Julie Y Tse1, Amanda C Pawlak, Chakib Boussahmain

  • 1Harvard Medical School, Boston, MA, USA.

The American Journal of Dermatopathology
|December 11, 2012
PubMed
Summary
This summary is machine-generated.

Rare skin cancers, basal cell carcinoma (BCC) with osteosarcomatous differentiation, were analyzed. Molecular analysis revealed TP53 mutations in one case, offering insights into these rare tumors.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Sarcomatoid carcinomas, including basal cell carcinoma (BCC) with osteosarcomatous differentiation, are exceptionally rare skin malignancies.
  • Only 11 cases of BCC with an osteosarcomatous component have been documented, with limited molecular data available.

Observation:

  • This study details two cases of basal cell carcinoma with osteosarcomatous differentiation, including clinical and histological features.
  • Immunohistochemistry confirmed the epithelial origin of the BCC component (BerEP4+, high-molecular-weight cytokeratin+) and the mesenchymal nature of the sarcomatous component (negative for both markers).

Findings:

  • Molecular analysis identified a TP53 mutation in one case, with p53 protein expression observed in both the epithelial and sarcomatous components.
  • The second case showed no TP53 mutation and lacked p53 expression in either component, highlighting potential heterogeneity in the molecular drivers of this rare tumor type.

Implications:

  • These findings contribute to the limited molecular understanding of basal cell carcinoma with osteosarcomatous differentiation.
  • Further research into the molecular mechanisms of sarcomatoid skin cancers is warranted to improve diagnosis and treatment strategies.