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Related Experiment Videos

Amyloidosis with oral involvement. Case report.

F C Loh1, N Ravindranathan, J F Yeo

  • 1Department of Oral Surgery, National University of Singapore.

Australian Dental Journal
|February 1, 1990
PubMed
Summary

A patient with chronic renal failure developed oral amyloidosis, a rare complication of multiple myeloma. Despite treatment, the condition progressed, leading to end-stage renal failure.

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Area of Science:

  • Nephrology
  • Hematology
  • Oral Medicine

Background:

  • Amyloidosis is a rare condition involving the buildup of abnormal proteins in organs.
  • Multiple myeloma is a cancer of plasma cells that can lead to amyloidosis.
  • Chronic renal failure necessitates careful management of associated complications.

Observation:

  • A patient with chronic renal failure presented with oral discomfort.
  • Oral examination revealed macroglossia and generalized oral soft tissue amyloidosis.
  • The patient had a history of Carpal-tunnel syndrome, a known association with amyloidosis.

Findings:

  • Diagnostic workup confirmed multiple myeloma as the underlying cause.
  • Amyloidosis significantly involved the oral soft tissues, presenting as macroglossia.
  • The patient initially responded to melphalan hydrochloride treatment.

Implications:

  • This case highlights the importance of recognizing oral manifestations of systemic diseases like multiple myeloma.
  • Early diagnosis and management of amyloidosis in chronic renal failure patients are crucial.
  • Understanding the link between Carpal-tunnel syndrome, multiple myeloma, and amyloidosis aids in comprehensive patient care.

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