Related Experiment Video
Updated: May 16, 2026

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
Published on: October 4, 2021
Levodopa/carbidopa to improve motor function subsequent to brain tumor excision
Jesse D Ennis1, David Harvey, Enoch Ho
1Physical Medicine and Rehabilitation Training Program, Department of Postgraduate Medicine, McMaster University, Hamilton, Canada.
Objective:
The aim of this study was to evaluate the role of levodopa/carbidopa as an augmenting agent to improve motor recovery after brain tumor excision.
Design:
This case report is structured as an n-of-1 style trial. The study patient was an outpatient with residual hemiparesis secondary to removal of benign oligoastrocytoma seen in an outpatient physiatry practice at an academic center. The study intervention was levodopa/carbidopa vs. placebo, combined with a structured 6-wk physiotherapy regimen. Outcomes were measured using the motor subscale of the Fugl-Meyer Assessment to assess for motor recovery.
Results:
The mean motor Fugl-Meyer Assessment score for the levodopa/carbidopa weeks was 6.90 points greater than the mean score for placebo. The results were significant at P < 0.05.
Conclusions:
Levodopa/carbidopa may have a beneficial effect on improving motor recovery after sustaining a brain injury as a result of tumor excision.
Related Concept Videos
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson Disease l: Introduction
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Phenothiazines, such as prochlorperazine...
Parkinson's Disease: Overview
