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Related Experiment Video

Updated: May 16, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
08:05

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Published on: March 17, 2020

TLI in refractory chronic GVHD.

R Devillier1, L Castagna, L Gonzague

  • 1Department of Hematology, Transplantation Program, Institut Paoli Calmettes, Marseille, France.

Bone Marrow Transplantation
|December 11, 2012
PubMed
Summary
This summary is machine-generated.

Total lymphoid irradiation (TLI) shows promise for treating refractory chronic graft-versus-host disease (cGVHD) in transplant patients. TLI offers a potential alternative, improving survival outcomes in this challenging patient population.

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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

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Last Updated: May 16, 2026

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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Refractory chronic graft-versus-host disease (cGVHD) is a significant cause of morbidity post-transplantation.
  • Current treatment options lack a standardized care approach, necessitating alternative therapies.

Purpose of the Study:

  • To evaluate the efficacy of Total Lymphoid Irradiation (TLI) in patients with corticosteroid-refractory cGVHD.
  • To assess response rates and clinical outcomes following TLI treatment.

Main Methods:

  • Retrospective analysis of 31 patients with refractory cGVHD treated with TLI between 2000 and 2007.
  • Evaluation of response based on decreased corticosteroid doses or discontinued immunosuppressive agents.
  • Assessment of GVHD-related mortality and overall survival (OS).

Main Results:

  • 45% of patients achieved an objective response to TLI.
  • 25% of patients were free of cGVHD at long-term follow-up.
  • TLI response significantly improved 5-year GVHD-related mortality (14% vs. 42%, P=0.038).

Conclusions:

  • TLI demonstrates a promising response rate in heavily pretreated patients with refractory cGVHD.
  • TLI may serve as a viable alternative treatment option for corticosteroid-refractory cGVHD.
  • Further investigation into TLI's role in managing cGVHD is warranted.