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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...

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Related Experiment Video

Updated: May 16, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Long non-coding RNAs and p53 regulation.

Antonella Baldassarre1, Andrea Masotti

  • 1Gene Expression-Microarrays Laboratory, IRCCS-Bambino Gesù Children's Hospital, Rome 00165, Italy. andrea.masotti@opbg.net.

International Journal of Molecular Sciences
|December 11, 2012
PubMed
Summary

Long non-coding RNAs (lncRNAs) are key regulators in biological processes. This review explores lncRNAs interacting with the p53 pathway, highlighting their diagnostic and therapeutic potential.

Area of Science:

  • Genomics
  • Molecular Biology
  • RNA Biology

Background:

  • High-throughput sequencing has revealed a vast landscape of non-coding RNAs.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized as critical regulators in cellular functions.
  • The p53 pathway is a central regulator in numerous biological conditions and diseases.

Purpose of the Study:

  • To review the roles of lncRNAs that are regulated by or regulate the p53 pathway.
  • To highlight the significance of lncRNA-p53 interactions in various biological contexts.
  • To discuss the need for advanced computational tools and strategies for lncRNA research.

Main Methods:

  • Literature review and synthesis of existing research on lncRNAs and the p53 pathway.
  • Analysis of studies investigating the interplay between lncRNAs and p53.

Related Experiment Videos

Last Updated: May 16, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

  • Discussion of emerging computational approaches for lncRNA functional characterization.

    • Main Results:

    • Identified numerous lncRNAs that directly or indirectly interact with the p53 pathway.
    • Demonstrated the involvement of these lncRNAs in diverse biological processes regulated by p53.
    • Highlighted the potential of lncRNAs as biomarkers and therapeutic targets.

    Conclusions:

    • lncRNAs play crucial roles in p53-mediated cellular processes.
    • Understanding lncRNA-p53 interactions is vital for deciphering complex biological mechanisms.
    • Novel computational tools and strategies are essential for advancing lncRNA research and its clinical applications.