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Updated: May 16, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Synthesis and antiviral activity of conformational analogues of leucamide A
Wen-Long Wang1, Hai-Jun Chen, Wei-Ping Ma
1School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China.
Abstract:
In order to study the effect of heterocyclic core conformational state of leucamide A on its anti-influenza virus A activity, five conformational analogues were prepared by replacing the Pro-Leu dipeptide in the molecule with various amino acids. The amino acids used were of 2 to 6 carbons. The results showed that these replacements not only changed the conformational relationship between the 4,2-bisheterocycle tandem pair and the third heterocycle, but also had dramatic effect on its activity against influenza virus A.
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