Related Experiment Video
Updated: May 8, 2026
07:47
The Slice Culture Method for Following Development of Tooth Germs In Explant Culture
Published on: November 13, 2013
Molecular regulatory mechanism of tooth root development
1Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
International Journal of Oral Science
|December 11, 2012
Summary
Understanding tooth root development is key for dental health and regeneration. This review details crucial molecular mechanisms and cell interactions in root formation, paving the way for future regenerative therapies.
Area of Science:
- Developmental Biology
- Dental Science
- Regenerative Medicine
Background:
- Tooth crown development is well-understood, but tooth root development remains largely unknown.
- A healthy tooth root is essential for the physiological function of the tooth and the success of dental restorations like artificial crowns.
Purpose of the Study:
- To review the current understanding of tooth root development processes.
- To summarize signaling cascades and molecular mechanisms involved in root formation.
- To provide a foundation for future research in de novo tooth regeneration.
Main Methods:
- Literature review of existing research on tooth root development.
- Synthesis of information on cell fate determination, differentiation, and cell interactions.
- Analysis of molecular signaling pathways involved in root formation.
Main Results:
- Detailed overview of cell fate determination during root development.
- Explanation of odontoblast and cementoblast differentiation induction.
- Elucidation of root epithelium and mesenchyme interactions and molecular mechanisms.
Conclusions:
- Significant progress has been made in understanding tooth root development.
- Current knowledge highlights key molecular signaling pathways and cellular interactions.
- This review establishes a framework for advancing de novo tooth regeneration strategies.
Related Concept Videos
01:51Determination
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
02:23Master Transcription Regulators
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
01:24Regulation of Angiogenesis and Blood Supply
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
01:15Teeth
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
01:21Tooth Anatomy
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.