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Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
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Relationship between age and prostate size.

Shi-Jun Zhang1, Hai-Ning Qian, Yan Zhao

  • 1Department of Ultrasound, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.

Asian Journal of Andrology
|December 11, 2012
PubMed
Summary

Prostate size naturally increases with age in men aged 40-70, with transition zone enlargement driving most of the growth. This age-related prostate growth correlates with International Prostate Symptom Score.

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Area of Science:

  • Urology
  • Gerontology
  • Medical Imaging

Background:

  • Prostate size naturally increases with age.
  • Understanding normal prostate growth patterns is crucial for diagnosing and managing conditions like benign prostatic hyperplasia (BPH).

Purpose of the Study:

  • To determine the normal prostate increase curve equation in men aged 40-70.
  • To investigate the relationship between age and various prostate parameters, including transition zone volume.
  • To correlate prostate parameters with International Prostate Symptom Score (IPSS).

Main Methods:

  • Community-based study involving 1000 male volunteers aged 40-70.
  • Transrectal ultrasound (TRUS) used to measure prostate dimensions and volume.
  • International Prostate Symptom Score (IPSS) administered to assess lower urinary tract symptoms.

Main Results:

  • All measured prostate parameters (length, width, height, volume) showed a positive association with increased age.
  • Transition zone volume (TZV) exhibited a higher increase rate with age compared to total prostate volume (TPV).
  • Prostate parameters, particularly TZ length (TZL) and TZV, showed the strongest positive correlation with IPSS.

Conclusions:

  • Prostate size significantly increases with age in men aged 40-70.
  • Enlargement of the transition zone is the primary contributor to the overall increase in total prostate volume with age.
  • Age-related prostate growth and transition zone enlargement are associated with lower urinary tract symptoms.