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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
Low wall shear stress is independently associated with the rupture status of middle cerebral artery aneurysms
Yoichi Miura1, Fujimaro Ishida, Yasuyuki Umeda
1Department of Neurosurgery, Mie Chuo Medical Center, National Hospital Organization, 2158-5 Hisai-Myojin Cho, Tsu City, Mie 514-1101, Japan.
Background And Purpose:
We determined which hemodynamic parameter independently characterizes the rupture status of middle cerebral artery (MCA) aneurysms using computational fluid dynamics analysis.
Methods:
In 106 patient-specific geometries of MCA aneurysms (43 ruptured, 63 unruptured), morphological and hemodynamic parameters were compared between the ruptured and unruptured groups. Multivariate logistic regression analysis was performed to determine parameters that independently characterized the rupture status of MCA aneurysms.
Results:
Univariate analyses showed that the aspect ratio, wall shear stress (WSS), normalized WSS, oscillatory shear index, WSS gradient, and aneurysm-formation index were significant parameters. The size of the aneurysmal dome and the gradient oscillatory number were not significantly different between the 2 groups. With multivariate analyses, only lower WSS was significantly associated with the rupture status of MCA aneurysms.
Conclusions:
WSS may be the most reliable parameter characterizing the rupture status of MCA aneurysms.
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