Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Diabetes Insipidus II: Pathophysiology

Diabetes Insipidus II: Pathophysiology

Normally, water balance is maintained through three interconnected mechanisms: the hypothalamic thirst center, the synthesis and release of antidiuretic hormone (ADH, or vasopressin), and the kidneys' responsiveness to this hormone. ADH is synthesized in the hypothalamus, released from the posterior pituitary, and acts on the distal nephron, allowing water reabsorption and concentrated urine production.Diabetes Insipidus and Its TypesIn diabetes insipidus (DI), this regulatory system is...

Disorder of Water Balance

Disorder of Water Balance

Water balance disorders are medical conditions that occur when there is a deviation from the body's water volume or osmolarity, disrupting normal homeostasis and leading todehydration, hypotonic hydration, hyperhydration, edema, or water intoxication.
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...

Diabetes Insipidus I: Introduction

Diabetes Insipidus I: Introduction

Definition Diabetes insipidus is a disorder marked by the production of large amounts of dilute urine because of impaired vasopressin production, release, or kidney response. The lack of effective vasopressin action limits water reabsorption in the renal collecting ducts, which leads to excessive urinary water loss and intense thirst.Clinical PresentationIndividuals with diabetes insipidus report persistent thirst and very high urine output. In severe cases, fluid intake can reach up to 20...

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...

Nephrotic Syndrome III : Nursing Management

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...

Nephrotic Syndrome II : Assessment and Medical Management

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Microcell-mediated transfer of chromosome 4 into HeLa cells suppresses telomerase activity.

Genes, chromosomes & cancer·2001

Same author

Fabrication of a single-appointment emergency overdenture using failed fixed prosthetics: a case report.

Implant dentistry·2001

Same author

Quality of life after treatment for early laryngeal carcinoma.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2001

Same author

HPV16 L1E7 chimeric virus-like particles induce specific HLA-restricted T cells in humans after in vitro vaccination.

International journal of cancer·2001

Same author

Endoscopic axillary lymphadenectomy without prior liposuction in 100 patients with invasive breast cancer.

Surgical laparoscopy, endoscopy & percutaneous techniques·2001

Same author

The application of fetal magnetocardiography (FMCG) to investigate fetal arrhythmias and congenital heart defects (CHD).

Prenatal diagnosis·2001

Same journal

[Promoting young academics in anesthesiology: factors for an attractive internship].

Der Anaesthesist·2022

Same journal

[Respiratory support in COVID-19: all in due time!]

Der Anaesthesist·2022

Same journal

[Noninvasive respiratory support and invasive ventilation in COVID‑19 : Where do we stand today?]

Der Anaesthesist·2022

Same journal

[Management of acutely decompensated liver cirrhosis in emergency and critical care medicine].

Der Anaesthesist·2022

Same journal

[Anesthesia in patients with acute porphyria].

Der Anaesthesist·2022

Same journal

[Quality and safe anesthesia for all children : That is their right!]

Der Anaesthesist·2022

See all related articles

Search research articles

Related Experiment Video

Updated: May 16, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

[Severe hypernatremia. Case report, pathophysiology and therapy].

A Schneider¹, M Reiner, F Kolibay

¹Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Köln-AöR, Kerpener Str. 62, 50937 Köln, Deutschland. andreas.schneider@uk-koeln.de

Der Anaesthesist

|December 11, 2012

Summary

This summary is machine-generated.

This case study highlights a patient with severe hypernatremia due to diabetes insipidus. Slow correction of high sodium levels over four days led to a full recovery, emphasizing cautious therapeutic approaches.

More Related Videos

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

Related Experiment Videos

Last Updated: May 16, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

Area of Science:

Neuro-oncology
Endocrinology
Intensive Care Medicine

Background:

Suprasellar optic gliomas can impact pituitary function, leading to endocrine disorders.
Diabetes insipidus is characterized by impaired water balance, potentially causing severe hypernatremia.
Hypernatremia, or high sodium levels, presents a critical challenge in intensive care settings.

Observation:

A female patient with a suprasellar optic glioma presented with decompensated diabetes insipidus.
Her serum sodium concentration reached a critical level of 194 mmol/l.
The patient required intensive care unit admission for management of this severe electrolyte imbalance.

Findings:

The patient's sodium concentration was gradually reduced over a four-day period.
This slow correction strategy resulted in complete recovery without any lasting neurological or physiological sequelae.
The case underscores the importance of careful management in hypernatremic conditions.

Implications:

Understanding the pathophysiology of hypernatremia, including cellular osmolyte regulation, is crucial for safe treatment.
Rapid correction of hypernatremia can lead to dangerous complications like cerebral edema.
Therapeutic strategies for hypernatremia must prioritize gradual sodium level normalization to prevent adverse outcomes.