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[Biomarkers and personalized medicine]
H U Scherer1, G-R Burmester, T Häupl
1Klinik für Rheumatologie, Leiden University Medical Center, 2300 RC, Leiden, Niederlande. h.u.scherer@lumc.nl
Zeitschrift Fur Rheumatologie
|December 11, 2012
Summary
Biomarkers enable personalized medicine by stratifying patients for targeted therapies. Autoantibodies in rheumatoid arthritis exemplify how specific markers improve treatment efficacy and safety.
Area of Science:
- Rheumatology and Immunology
- Biomarker Discovery
- Personalized Medicine
Context:
- Biomarkers are crucial for patient stratification and individualized treatment strategies in rheumatic diseases.
- Understanding pathophysiological processes yields novel biomarkers and enhances the use of established markers.
- Autoantibodies in rheumatoid arthritis (RA) identify patient subgroups with distinct risk profiles and therapeutic responses.
Purpose:
- To highlight the increasing importance of biomarkers in tailoring medical treatments.
- To emphasize the role of autoantibodies in rheumatoid arthritis classification and management.
- To discuss the integration of novel biomarkers into personalized medicine approaches.
Summary:
- Biomarkers are foundational for stratifying patients and developing personalized treatment strategies.
- Established markers like autoantibodies in RA are integrated into classification criteria and guidelines.
- Novel biomarkers are continuously being evaluated, paving the way for more precise therapeutic targeting.
Impact:
- Personalized medicine will increasingly link therapeutic substance eligibility to specific biomarker detection.
- This approach is expected to enhance treatment efficacy and patient safety.
- While potentially reducing the number of eligible patients for certain treatments, it promises improved outcomes and cost-effectiveness.
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