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Updated: May 16, 2026

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Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
Published on: January 7, 2019
Long-term vagus nerve stimulation for severe refractory depression: a case study with a six-year follow-up
The Journal of Neuropsychiatry and Clinical Neurosciences
|December 11, 2012
Abstract
No abstract available in PubMed .
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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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