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Updated: May 16, 2026
09:25
Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells
Published on: August 19, 2016
Modulation of the coagulation system during severe streptococcal disease
Oonagh Shannon1, Heiko Herwald, Sonja Oehmcke
1Division of Infection Medicine, Department of Clinical Sciences, Biomedical Centre, B14, Lund University, Sweden. oonagh.shannon@med.lu.se
Current Topics in Microbiology and Immunology
|December 11, 2012
Summary
Streptococcus pyogenes manipulates the blood coagulation system during infection. This review explores the molecular mechanisms behind how this bacterium affects hemostasis and fibrinolysis.
Area of Science:
- Microbiology
- Hematology
- Immunology
Background:
- Hemostasis is regulated by platelets and coagulation proteins.
- Bacterial infections can activate the coagulation system.
- Streptococcus pyogenes is a significant human pathogen.
Purpose of the Study:
- To review the molecular mechanisms by which Streptococcus pyogenes modulates the host coagulation system.
- To discuss the diverse effects of S. pyogenes on hemostasis and fibrinolysis.
Main Methods:
- Literature review of host-pathogen interactions.
- Analysis of molecular strategies employed by S. pyogenes.
- Discussion of coagulation and fibrinolysis pathways.
Main Results:
- S. pyogenes employs multiple strategies to modulate coagulation.
- Coagulation system activation occurs both locally and systemically.
- Bacterial modulation includes effects on intrinsic/extrinsic pathways and fibrinolysis.
Conclusions:
- There is a finely tuned interaction between S. pyogenes and the host coagulation system.
- Understanding these mechanisms is crucial for addressing S. pyogenes infections.
- The review highlights the complex interplay between bacterial pathogens and host hemostasis.
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