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HLA-A, B, C and DR antigens in nickel contact sensitivity
N Mozzanica1, L Rizzolo, G Veneroni
1Department of Dermatology, University of Milan, Italy.
The British Journal of Dermatology
|March 1, 1990
Abstract:
The relationship between HLA antigens (A, B, C and DR) and nickel contact sensitivity was examined in 54 patients with contact allergy, as confirmed by an unequivocal positive patch-test reaction only to nickel. A control group was 320 healthy blood donors from the same geographical area as the patients. The HLA-A, B, C and DR antigens were typed using standard serological methods. HLA typing revealed a significant increase of HLA-DRw6 antigen in the patient group (corrected P less than 0.025) and the relative risk for patients with DRw6 to develop nickel sensitivity was 3.32.