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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
What is the Immune System?01:38

What is the Immune System?

Overview
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

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Related Experiment Video

Updated: May 16, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

GW/P-bodies and autoimmune disease.

Donald B Bloch1, Rita A Nobre, Wei-Hong Yang

  • 1The Department of Medicine, Harvard Medical School, Boston, MA, USA. bloch@helix.mgh.harvard.edu

Advances in Experimental Medicine and Biology
|December 11, 2012
PubMed
Summary

Human autoantibodies are crucial for identifying GW/P-body components and understanding their cellular roles. Further research into GW/P-bodies may illuminate their connection to autoimmune disease pathogenesis.

Area of Science:

  • Cell Biology
  • Immunology
  • Molecular Biology

Background:

  • GW/P-bodies are crucial cellular structures involved in mRNA regulation.
  • Human autoantibodies have been instrumental in identifying GW/P-body components.
  • Previous research has identified proteins like Ge-l, GW182, RAP55, and YB-1 as GW/P-body constituents.

Purpose of the Study:

  • To highlight the role of human autoantibodies in characterizing GW/P-bodies.
  • To discuss the identification of novel GW/P-body components.
  • To explore the potential functional link between GW/P-bodies and PML-Sp100 nuclear bodies.
  • To emphasize the need to investigate the role of GW/P-bodies in autoimmune disease pathogenesis.

Main Methods:

  • Utilizing human autoantibodies for GW/P-body characterization.

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Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
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Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

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Last Updated: May 16, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

  • Employing high-throughput screening assays for novel component identification.
  • Investigating potential functional links between cellular structures.

    • Main Results:

    • Human autoantibodies have successfully identified known and novel GW/P-body components.
    • New screening assays are expected to discover additional GW/P-body constituents.
    • Autoantibodies suggest a functional connection between GW/P-bodies and PML-Sp100 nuclear bodies.

    Conclusions:

    • Human autoantibodies are vital tools for GW/P-body research.
    • GW/P-bodies and PML-Sp100 nuclear bodies may be functionally linked.
    • The role of GW/P-bodies in autoimmune disease pathogenesis requires further investigation.