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Prion protein aggregation and fibrillogenesis in vitro

Jan Stöhr1

  • 1Institute for Neurodegenerative Diseases, University of California, 94143-0518, San Francisco, CA, USA, jstoehr@ind.ucsf.edu.

Sub-Cellular Biochemistry
|December 11, 2012
PubMed
Summary

Prion diseases involve the structural conversion of cellular prion protein (PrP(C)) to the disease-associated PrP(Sc) isoform. In vitro studies demonstrate this conversion and the creation of synthetic prions, supporting the protein-only hypothesis.

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