Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Subviral Agents

Subviral Agents

Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...

Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...

Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...

Bacterial Phylum Spirochaetes

Bacterial Phylum Spirochaetes

Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased by a...

Parkinson Disease ll: Pathophysiology

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Contact Networks of Small Mammals Highlight Potential Transmission Foci of Mammarenavirus lassaense.

The American journal of tropical medicine and hygiene·2026

Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Same author

The Phenotypic Spectrum of Sporadic Creutzfeldt-Jakob Disease Cortical Subtype.

Annals of neurology·2025

Same author

Land use gradients drive spatial variation in Lassa fever host communities in the Eastern Province of Sierra Leone.

The Journal of animal ecology·2025

Same author

Unsuccessful transmissions of atypical genetic Creutzfeldt-Jakob disease (PRNP p.T183A-129M) in transgenic mice.

Acta neuropathologica·2024

Same author

Fast-track neuropathological screening for neurodegenerative diseases.

Free neuropathology·2024

Search research articles

Related Experiment Video

Updated: May 16, 2026

Procedures for Identifying Infectious Prions After Passage Through the Digestive System of an Avian Species

Procedures for Identifying Infectious Prions After Passage Through the Digestive System of an Avian Species

Published on: November 6, 2013

Animal prion diseases.

Otto Windl¹, Mike Dawson

¹Animal Health and Veterinary Laboratories Agency, KT15 3NB, New Haw, United Kingdom, otto.windl@ahvla.gsi.gov.uk.

Sub-Cellular Biochemistry

|December 11, 2012

Summary

Animal prion diseases like BSE and scrapie are a concern, with new atypical forms raising questions about transmissibility. Control measures are in place, but vigilance is needed to protect animal and public health.

Area of Science:

Veterinary Medicine
Neuroscience
Infectious Diseases

Background:

Prion diseases, including scrapie in sheep/goats and Bovine Spongiform Encephalopathy (BSE) in cattle, affect various animal species.
BSE, a novel disease emerging in the 1980s, is linked to prion-contaminated animal feed and human transmission.
Atypical forms of BSE and scrapie present ongoing challenges regarding the spectrum of prion diseases and interspecies transmissibility.

Purpose of the Study:

To review the pathogenesis, diagnosis, and control of animal prion diseases.
To highlight the challenges posed by emerging atypical prion diseases.
To emphasize the need for continued vigilance in safeguarding animal and public health.

Main Methods:

Study of pathogenesis in natural infections and experimental animal models.

More Related Videos

Assessing Transmissible Spongiform Encephalopathy Species Barriers with an In Vitro Prion Protein Conversion Assay

Assessing Transmissible Spongiform Encephalopathy Species Barriers with an In Vitro Prion Protein Conversion Assay

Published on: March 10, 2015

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material

Published on: September 29, 2017

Related Experiment Videos

Last Updated: May 16, 2026

Procedures for Identifying Infectious Prions After Passage Through the Digestive System of an Avian Species

Procedures for Identifying Infectious Prions After Passage Through the Digestive System of an Avian Species

Published on: November 6, 2013

Assessing Transmissible Spongiform Encephalopathy Species Barriers with an In Vitro Prion Protein Conversion Assay

Assessing Transmissible Spongiform Encephalopathy Species Barriers with an In Vitro Prion Protein Conversion Assay

Published on: March 10, 2015

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material

Published on: September 29, 2017

Utilizing rodent models, particularly transgenic mice, for infectivity detection.

Post-mortem diagnosis based on detecting abnormal prion protein (PrP(Sc)).

Main Results:

Clinically affected animals exhibit characteristic neuropathology and accumulation of PrP(Sc).
A routine ante-mortem diagnostic test for prion diseases remains elusive.
Prions are environmentally persistent, complicating decontamination efforts.

Conclusions:

Current control strategies include movement restrictions, culling, and selective breeding for genetic resistance.
Effective control of BSE was achieved through feed ban restrictions.
The evolving landscape of prion diseases necessitates ongoing vigilance to protect animal and public health.