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Related Experiment Videos

Plasma exchange in refractory cutaneous vasculitis.

A N Turner1, S Whittaker, I Banks

  • 1Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.

The British Journal of Dermatology
|March 1, 1990
PubMed
Summary
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Plasma exchange therapy shows significant promise for treating severe cutaneous vasculitis. This treatment led to substantial improvement in most patients with refractory disease, offering a valuable therapeutic option.

Area of Science:

  • Immunology
  • Dermatology
  • Nephrology

Background:

  • Cutaneous leucocytoclastic vasculitis is a challenging condition.
  • Intractable cases require novel therapeutic approaches.

Purpose of the Study:

  • To evaluate the efficacy and safety of plasma exchange therapy in patients with severe refractory cutaneous vasculitis.

Main Methods:

  • Eight patients with intractable cutaneous leucocytoclastic vasculitis underwent plasma exchange therapy.
  • Treatment duration varied, with some patients receiving intermittent plasma exchange for up to 12 years.

Main Results:

  • Seven out of eight patients demonstrated improvement, with five experiencing substantial benefits.
  • Long-term intermittent plasma exchange proved successful in four patients.

Related Experiment Videos

  • One case of hepatitis B was noted, potentially linked to fresh frozen plasma, with no other major adverse events reported.

    • Conclusions:

    • Plasma exchange is a potentially valuable therapeutic option for severe, refractory cutaneous vasculitis.
    • The treatment demonstrates a favorable safety profile for long-term management.