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Bilaterality of drusen.

M Barondes¹, D Pauleikhoff, I C Chisholm

¹Department of Clinical and Preventive Ophthalmology, Moorfields Eye Hospital, London.

The British Journal of Ophthalmology

|March 1, 1990

Summary

Drusen in both eyes showed remarkable similarity in size, number, density, and fluorescence. This suggests a specific metabolic issue unique to the individual, rather than a general aging process, may cause these age-related disease manifestations.

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Area of Science:

Ophthalmology
Gerontology
Metabolic Disorders

Background:

Drusen are characteristic of age-related macular degeneration (AMD).
Bilateral drusen are common in patients with AMD.
The symmetry of drusen characteristics between eyes is not well understood.

Purpose of the Study:

To analyze the symmetry of drusen characteristics between the two eyes in patients with bilateral drusen.
To investigate the underlying cause of drusen formation in age-related disease.

Main Methods:

Analysis of drusen characteristics (size, number, density, fluorescence) in 81 patients with bilateral drusen.
Comparison of these characteristics between the left and right eyes.

Main Results:

A close concordance was observed in drusen size, number, density, and fluorescence between the two eyes.
This symmetry was statistically significant, exceeding chance expectations.

Conclusions:

The findings suggest that drusen formation in age-related disease may stem from a patient-specific metabolic malfunction.
This contrasts with the hypothesis that drusen are a non-specific result of the aging process.

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