Related Experiment Video

Updated: May 16, 2026

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
04:30

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

Inflammation is associated with the remodeling of calcific aortic valve disease

Nancy Coté1, Ablajan Mahmut, Yohan Bosse

  • 1Laboratoire d'Études Moléculaires des Valvulopathies-LEMV, Groupe de Recherche en Valvulopathies-GRV, Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada.

Inflammation
|December 11, 2012
PubMed

Insights

Calcific aortic valve disease (CAVD) involves inflammation. This study found that inflammation in CAVD tissue is linked to aortic stenosis severity and progression.

Area of Science:

  • Cardiovascular Medicine
  • Pathology
  • Inflammation Research

Background:

  • Calcific aortic valve disease (CAVD) is a common heart valve disorder.
  • Mineralization in CAVD may be linked to inflammation, but clinical evidence is limited.

Purpose of the Study:

  • To investigate the relationship between chronic inflammatory infiltrates in CAVD and the clinical evolution of aortic stenosis.

Main Methods:

  • Histological analysis of aortic valves from 285 CAVD patients.
  • Correlation of inflammatory infiltrates with hemodynamic severity.
  • Leukocyte density and TNF-α transcript analysis in a subset of 57 patients.

Main Results:

  • Chronic inflammatory infiltrates were found in 28.4% of CAVD tissues.
  • Inflammation was associated with active remodeling and peak transaortic gradient.
  • Leukocyte density correlated with the progression rate of aortic stenosis.

Conclusions:

  • Dense inflammatory infiltrate in CAVD is associated with active remodeling.
  • Inflammation correlates with aortic stenosis severity and hemodynamic progression.
  • Inflammation plays a role in the clinical course of calcific aortic valve disease.

More Related Videos

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro05:47

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

Isolation of Human Primary Valve Cells for In vitro Disease Modeling07:31

Isolation of Human Primary Valve Cells for In vitro Disease Modeling

Published on: April 16, 2021

Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammation01:38

Inflammation

Overview