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Updated: May 16, 2026

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

Cancer-related inflammation.

Juliana Candido¹, Thorsten Hagemann

¹Centre for Cancer and Inflammation, Barts Cancer Institute, Queen Mary, University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.

Journal of Clinical Immunology

|December 11, 2012

Summary

Cancer-associated inflammation fuels tumor growth and spread. Macrophage migratory inhibitory factor (MIF) is a key cytokine in this inflammatory tumor microenvironment, impacting cancer progression and treatment response.

Area of Science:

Oncology
Immunology
Cell Biology

Background:

Solid tumors comprise neoplastic, stromal, and hematopoietic cells, forming a complex microenvironment.
Inflammation is integral to the tumor microenvironment, influencing tumor growth, metastasis, and angiogenesis.
Proinflammatory mediators, including cytokines, are crucial for intercellular communication within tumors.

Purpose of the Study:

To discuss the role of cancer-associated inflammation in malignant diseases.
To highlight the specific role of macrophage migratory inhibitory factor (MIF) in the tumor microenvironment.

Main Methods:

Review of scientific literature on cancer-associated inflammation and cytokines.
Analysis of the involvement of specific cytokines, including MIF, in various cancers.

Related Experiment Videos

Last Updated: May 16, 2026

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

Main Results:

Inflammation promotes malignant cell proliferation, survival, angiogenesis, and metastasis.
Cytokines like MIF, IL-6, and TNF-α are implicated in both promoting and inhibiting tumor development.
MIF is frequently overexpressed in cancers by both tumor cells and immune cells.

Conclusions:

Cancer-associated inflammation is a critical factor in tumor progression and treatment resistance.
Macrophage migratory inhibitory factor (MIF) plays a significant role in mediating cancer-associated inflammation and influencing disease outcomes.