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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
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Injectable bone tissue engineering using expanded mesenchymal stem cells.

Yoichi Yamada1, Sayaka Nakamura, Kenji Ito

  • 1Center for Genetic and Regenerative Medicine, Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan. yyamada@aichi-med-u.ac.jp

Stem Cells (Dayton, Ohio)
|December 11, 2012
PubMed
Summary

Injectable tissue-engineered bone using mesenchymal stem cells (MSCs) effectively regenerated bone in alveolar defects. This minimally invasive approach showed significant bone volume increase and restored function with no side effects.

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Orthopedic Surgery

Background:

  • Autologous bone transplants for bone defects have limitations and complications.
  • Stem cell therapy offers a promising alternative for bone regeneration.
  • Clinical applications of stem cells in bone tissue engineering are limited.

Purpose of the Study:

  • To evaluate the efficacy of injectable tissue-engineered bone (TEB) for alveolar bone defects.
  • To assess bone regeneration using mesenchymal stem cells (MSCs) and platelet-rich plasma.
  • To determine the long-term safety and functional outcomes of TEB treatment.

Main Methods:

  • Animal studies followed by large-scale clinical trials.
  • Minimally invasive transplantation of injectable TEB composed of MSCs and platelet-rich plasma.
  • Assessment of bone volume, new bone formation, and functional recovery.

Main Results:

  • Significant increase in bone volume observed at 3 months post-treatment (p < .001).
  • Newly formed bone reached levels comparable to native bone.
  • No significant bone resorption or adverse side effects reported during long-term follow-up.
  • Restoration of masticatory function in treated patients.

Conclusions:

  • Injectable TEB using MSCs is an effective therapeutic strategy for bone tissue engineering.
  • Minimally invasive MSC transplantation promotes functional bone regeneration in alveolar deficiencies.
  • This approach offers a safe and viable alternative to traditional bone grafting methods.