Molecular and epidemiological characterization of carbapenem-resistant Acinetobacter baumannii in non-tertiary Korean
Sunok Park1, Hwa-Su Kim, Kyeong Min Lee
1Division of Antimicrobial Resistance, Center for Infectious Diseases, Korea National Institute of Health, Cheongwon, Korea.
Purpose:
The increasing prevalence and global spread of carbapenem-resistant Acinetobacter baumannii (A. baumannii) has become a serious problem. The aim of this study was to investigate molecular and epidemiological characteristics of carbapenem-resistant A. baumannii isolates collected from Korean non-tertiary hospitals.
Materials And Methods:
Thirty six non-duplicated carbapenem-resistant A. baumannii isolates were collected from 17 non-tertiary hospitals in Korea between 2004 and 2006. Isolates were typed by multilocus sequence typing and repetitive-sequence-based PCR (rep-PCR). Detection of genes encoding OXA carbapenemase and their relationship with ISAba1 was performed by PCR.
Results:
Two clones were prevalent among 36 isolates: ST69 (17 isolates, 47.2%) and ST92 (19 isolates, 52.8%). Rep-PCR patterns were diverse and revealed that all isolates were clustered into eight band patterns. The ISAba1-activated blaOXA-23-like and ISAba1-activated blaOXA-51-like genes were prevalent among the carbapenem- resistant A. baumannii isolates.
Conclusion:
The class D β-lactamase genes of A. baumannii were distributed nationwide in non-tertiary Korean hospitals.
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