Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

Overview
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

Overview
Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction Note: Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II.

Nature communications·2026
Same author

Retraction Note: Targeting 17q23 amplicon to overcome the resistance to anti-HER2 therapy in HER2+ breast cancer.

Nature communications·2026
Same author

Retraction Note: Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance.

Nature communications·2026
Same author

Retraction Note: A biomimetic hybrid nanoplatform for encapsulation and precisely controlled delivery of theranostic agents.

Nature communications·2026
Same author

Retraction Note: Carbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance.

Nature communications·2026
Same author

Corrigendum to 'Hyaluronic acid-decorated dual responsive nanoparticles of Pluronic F127, PLGA, and chitosan for targeted co-delivery of doxorubicin and irinotecan to eliminate cancer stem-like cells' [Biomaterials 72 (2015) 17043].

Biomaterials·2026

Related Experiment Video

Updated: May 16, 2026

Analysis of Nonhomologous End Joining and Homologous Recombination Efficiency in HEK-293T Cells Using GFP-Based Reporter Systems
09:29

Analysis of Nonhomologous End Joining and Homologous Recombination Efficiency in HEK-293T Cells Using GFP-Based Reporter Systems

Published on: February 2, 2024

Non-coding RNAs in DNA damage response.

Yunhua Liu1, Xiongbin Lu

  • 1Department of Cancer Biology, Metastasis Research Center, The University of Texas MD Anderson Cancer Center Houston, Texas 77030, USA.

American Journal of Cancer Research
|December 11, 2012
PubMed
Summary

Regulatory non-protein-coding RNAs (ncRNAs) are crucial for maintaining genome stability by modulating the DNA damage response (DDR). This review highlights how ncRNAs and the DDR pathway mutually regulate each other, impacting genome integrity.

Keywords:
DNA damage responsecrosstalklncRNAsmiRNAsncRNAs

More Related Videos

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
10:44

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage

Published on: January 31, 2018

Proximity Ligand Assay to Localize Proteins in DNA Damage Sites
09:39

Proximity Ligand Assay to Localize Proteins in DNA Damage Sites

Published on: August 2, 2024

Related Experiment Videos

Last Updated: May 16, 2026

Analysis of Nonhomologous End Joining and Homologous Recombination Efficiency in HEK-293T Cells Using GFP-Based Reporter Systems
09:29

Analysis of Nonhomologous End Joining and Homologous Recombination Efficiency in HEK-293T Cells Using GFP-Based Reporter Systems

Published on: February 2, 2024

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
10:44

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage

Published on: January 31, 2018

Proximity Ligand Assay to Localize Proteins in DNA Damage Sites
09:39

Proximity Ligand Assay to Localize Proteins in DNA Damage Sites

Published on: August 2, 2024

Area of Science:

  • Genomics
  • Molecular Biology
  • Epigenetics

Background:

  • Mammalian genomes are pervasively transcribed, producing numerous regulatory non-protein-coding RNAs (ncRNAs).
  • Emerging evidence indicates ncRNAs are vital for genome integrity and stability.
  • ncRNAs play a key role in regulating the DNA damage response (DDR).

Purpose of the Study:

  • To review the interplay between ncRNAs and the canonical DDR signaling pathway.
  • To emphasize the roles of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in DDR.
  • To describe the function of Dicer- and Drosha-dependent small RNAs at double-strand break sites.

Main Methods:

  • Literature review of recent findings on ncRNA-DDR interactions.
  • Focus on regulatory mechanisms involving miRNAs and lncRNAs.
  • Analysis of small RNA production in response to DNA damage.

Main Results:

  • ncRNA expression is regulated during the DDR.
  • DDR pathways are modulated by DNA damage-responsive ncRNAs.
  • Specific small RNAs are generated near double-strand breaks.

Conclusions:

  • ncRNAs are integral components of the DDR network.
  • The bidirectional regulation between ncRNAs and DDR is essential for maintaining genome stability.
  • Further research into ncRNA-mediated DDR mechanisms is warranted.