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Related Experiment Video

Updated: May 16, 2026

Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice
07:44

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Published on: February 17, 2023

Vanishing tumor in pregnancy.

M V Vimal1, Sweta Budyal, Rajeev Kasliwal

  • 1Department of Endocrinology, Seth G. S. Medical College, Mumbai, Maharashtra, India.

Indian Journal of Endocrinology and Metabolism
|December 11, 2012
PubMed
Summary

Management of a microprolactinoma during pregnancy is discussed. The tumor grew during the second pregnancy, requiring bromocriptine, but resolved post-delivery, showcasing successful reproductive outcomes.

Keywords:
Bromocriptinepregnancyprolactinoma

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Area of Science:

  • Endocrinology
  • Reproductive Medicine
  • Oncology

Background:

  • Prolactinomas are pituitary tumors that secrete prolactin, affecting reproductive function.
  • Pregnancy can influence prolactinoma size and management strategies.
  • Microprolactinomas are tumors less than 10 mm in diameter.

Observation:

  • A patient with a known microprolactinoma experienced two successful pregnancies.
  • During the second pregnancy, the tumor enlarged to a macroprolactinoma (≥10 mm).
  • Symptoms included headache and blurred vision, indicating potential mass effect.

Findings:

  • Medical management with bromocriptine effectively controlled tumor growth and symptoms during the second pregnancy.
  • Postpartum follow-up revealed complete resolution of the macroprolactinoma.
  • This case highlights the dynamic nature of prolactinomas during gestation.

Implications:

  • Bromocriptine is a safe and effective treatment for symptomatic prolactinoma enlargement during pregnancy.
  • Close monitoring and prompt management are crucial for successful pregnancy outcomes in patients with prolactinomas.
  • The potential for tumor regression after pregnancy warrants further investigation.