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Updated: May 16, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Stress increases periodontal inflammation
César Rivera1, Francisco Monsalve, Iván Suazo
1Unit of Histology and Embryology, Department of Basic Biomedical Sciences, Faculty of Health Sciences; ; Master Program in Biomedical Sciences, Oral Pathology mention, University of Talca, Talca;
Experimental and Therapeutic Medicine
|December 11, 2012
Summary
Chronic restraint stress (RS) in rats significantly worsened experimental periodontal disease, increasing gingival and bone inflammation. This study highlights stress as a modulator of periodontal inflammation, offering a suitable rat model for further research.
Area of Science:
- Oral biology
- Stress physiology
- Immunology
Background:
- Periodontal disease is a common inflammatory condition affecting the gums and supporting bone structures.
- Chronic stress is increasingly recognized as a factor influencing various health outcomes, including inflammatory diseases.
Purpose of the Study:
- To investigate the impact of chronic restraint stress (RS) on the severity of experimentally induced periodontal disease in a rat model.
- To establish a reliable animal model for studying the interplay between stress and periodontal health.
Main Methods:
- Thirty-two male Sprague Dawley rats were divided into four groups: stress plus periodontal disease, periodontal disease only, stress only, and control.
- Chronic restraint stress was induced daily for 15 days. Periodontal disease was induced using ligatures around the first left mandibular molars.
- Blood glucose and corticosterone levels were measured as stress indicators. Periodontal disease severity was assessed by gingival and bone inflammation levels.
Main Results:
- Chronic restraint stress significantly increased the severity of experimental periodontal disease.
- Both gingival and bone inflammation levels were higher in rats subjected to chronic stress and periodontal disease induction.
- Stress markers, including corticosterone levels, indicated a successful induction of chronic stress.
Conclusions:
- Chronic restraint stress exacerbates experimental periodontal disease in rats.
- The developed rat model effectively demonstrates that stress modulates periodontal inflammation.
- This model is suitable for future research into the association between stress and periodontal disease.
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