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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
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The role of AIB1 in breast cancer

Alan K Chang1, Huijian Wu

  • 1College of Life Science and Biotechnology, Dalian University of Technology, Dalian, Liaoning 116024, P.R. China.

Oncology Letters
|December 11, 2012
PubMed

Insights

Amplified in breast cancer 1 (AIB1) is crucial in both hormone-dependent and -independent breast cancers. Understanding AIB1

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Amplified in breast cancer 1 (AIB1) is a p160 steroid receptor coactivator.
  • AIB1 modulates nuclear receptors like ER and PR, and transcription factors such as E2F1 and p53.
  • It is implicated in various cancers, notably breast, prostate, gastric, and pancreatic.

Purpose of the Study:

  • To review the significant progress and current understanding of AIB1's influence on breast cancer.
  • To explore AIB1's roles in both hormone-dependent and hormone-independent signaling pathways.
  • To discuss the challenges in developing AIB1-targeted breast cancer therapies.

Main Methods:

  • Literature review of recent findings on AIB1.
  • Analysis of AIB1's involvement in nuclear receptor-mediated diseases.
  • Examination of AIB1's function in hormone-dependent and -independent breast cancer signaling.

Main Results:

  • AIB1 overexpression correlates with increased tumor incidence in mice.
  • Elevated AIB1 mRNA and protein levels are found in some breast cancer specimens.
  • AIB1 influences hormone-independent breast cancer growth through pathways like E2F1, IGF-I, EGF, and PI3K/Akt/mTOR.

Conclusions:

  • AIB1 plays a pleiotropic role in normal development and cancer.
  • Its involvement in diverse signaling pathways presents therapeutic challenges for breast cancer.
  • Further research is needed to effectively target AIB1 in breast cancer treatment.

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