Related Experiment Video
Updated: May 16, 2026

Mass Isolation and In Vitro Cultivation of Intramolluscan Stages of the Human Blood Fluke Schistosoma Mansoni
Published on: January 14, 2018
New frontiers in schistosoma genomics and transcriptomics.
Laila A Nahum1, Marina M Mourão, Guilherme Oliveira
1Genomics and Computational Biology Group, Centro de Pesquisas René Rachou (CPqRR), Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Fundação Oswaldo Cruz (FIOCRUZ), 30190-002 Belo Horizonte, MG, Brazil ; Centro de Excelência em Bioinformática (CEBio), Fundação Oswaldo Cruz (FIOCRUZ), 30190-110 Belo Horizonte, MG, Brazil ; Faculdade Infórium de Tecnologia, 30130-180 Belo Horizonte, MG, Brazil.
Genomic and transcriptomic research advances schistosome biology. Despite progress, challenges remain in understanding these parasitic flatworms, necessitating future research directions.
Area of Science:
- Parasitology
- Genomics
- Evolutionary Biology
Background:
- Schistosomes are digenean blood flukes, with some species causing human schistosomiasis, a major neglected tropical disease affecting millions.
- Modern molecular technologies enable large-scale analyses of parasites and hosts, advancing biological research.
Purpose of the Study:
- To discuss recent advances in schistosome research, focusing on genomics and transcriptomics.
- To highlight current challenges and propose future research directions in schistosome studies.
Main Methods:
- Sequencing and characterization of nuclear and mitochondrial genomes.
- DNA barcoding of mitochondrial sequences for biodiversity assessment.
- Large-scale analyses of parasite and host nucleic acids and proteins.
Main Results:
- Nuclear genomes of three key schistosome species (S. haematobium, S. japonicum, S. mansoni) have been sequenced.
- Mitochondrial genomes of six Schistosoma species have been sequenced and analyzed for evolutionary insights.
- DNA barcoding aids in schistosome biodiversity assessment.
Conclusions:
- Genomic and transcriptomic studies have significantly advanced schistosome research.
- Despite progress, many questions regarding schistosome biology and evolution persist.
- Future research should address current challenges and explore new directions in schistosome studies.
Related Concept Videos
Next-generation Sequencing
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Genomics
Pharmacogenomics: Identification of New Drug Targets

