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Updated: May 16, 2026

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
[Construction and application of natural products LC-MS-DS]
1State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center Beijing 100191, China.
Abstract:
To overcome the defects of current research methods of natural products, an LC-MS-DS that consisted of more than 600 natural products was constructed with HPLC-ESI-IT-MS/MS. The database searching results of LC-MS-DS were validated to be reliable, which indicated that LC-MS-DS could be successfully applied for the effective identification and target isolation of natural products. The study will provide an effective method for fast identification and efficient isolation of natural products.
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