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Updated: May 16, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
The role of iron overload on oxidative stress in sickle cell anemia
Talyta Ellen de Jesus Dos Santos1, Geane Félix de Sousa, Maritza Cavalcante Barbosa
1Department of Clinical & Toxicological Analysis of Federal University of Ceara, Fortaleza, Ceara, Brazil.
Unlabelled:
Repeated blood transfusions in patients with sickle cell anemia (SCA) increases the risk of iron overload (IO), contributing to oxidative stress.
Materials & Methods:
Blood samples of 15 SCA patients without IO (group 1) and 15 SCA patients with IO (group 2) and 30 healthy individuals were collected to investigate oxidative stress. IO was categorized using repeated measures of serum ferritin. The biomarkers evaluated were plasmatic malondialdehyde (MDA), nitrite and erythrocyte catalase.
Results:
MDA and nitrite were higher in group 2 than in group 1 and the healthy group (p < 0.001 for MDA and nitrite). Catalase presented lower in group 2 than group 1 and the healthy group (p < 0.001). We obtained a positive correlation between ferritin and MDA (r = 0.40; p < 0.02), and between ferritin and nitrite (r = 0359; p = 0.023).
Conclusion:
The results demonstrated that IO is an important risk factor for enhanced oxidative stress in SCA.
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