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Updated: May 16, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Asymmetric transfer hydrogenation coupled with dynamic kinetic resolution in water: synthesis of
Brinton Seashore-Ludlow1, François Saint-Dizier, Peter Somfai
1Organic Chemistry, Department of Chemical Science and Engineering, KTH Royal Institute of Technology, 100 44 Stockholm, Sweden. brinton@kth.se
Abstract:
The use of asymmetric transfer hydrogenation combined with dynamic kinetic resolution for the synthesis of β-hydroxy-α-(tert-butoxycarbonyl)amino esters in water is described. This procedure provides the desired amino alcohols in good yields, diastereoselectivities, and enantioselectivities. A surfactant is employed to achieve good yields due to the hydrophobic nature of both the catalyst and substrate. The reaction setup is operationally simple, and nondegassed water can be used as the solvent.
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