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Troponin T, B-type natriuretic peptide, C-reactive protein, and cause-specific mortality

Oludamilola W Oluleye1, Aaron R Folsom, Vijay Nambi

  • 1Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN 55454, USA.

Annals of Epidemiology
|December 12, 2012
PubMed

Insights

Elevated levels of high-sensitivity troponin T (Hs-TnT), N-terminal pro-brain natriuretic peptide (NT-proBNP), and high sensitivity C-reactive protein (Hs-CRP) predict higher mortality risk. These biomarkers are associated with death from cardiovascular and noncardiovascular causes.

Area of Science:

  • Biomarkers
  • Cardiovascular Disease
  • Mortality Prediction

Background:

  • Biomarkers like Hs-TnT, NT-proBNP, and Hs-CRP are crucial in assessing cardiovascular risk.
  • Understanding their association with various mortality causes is essential for public health.

Purpose of the Study:

  • To evaluate the associations of Hs-TnT, NT-proBNP, and Hs-CRP with all-cause, CVD, CHD, stroke, cancer, and respiratory mortality.
  • To investigate the impact of elevated levels of these biomarkers on specific mortality outcomes.

Main Methods:

  • Analysis of 11,193 participants aged 54-74 from the Atherosclerosis Risk in Communities cohort.
  • Biomarker levels (Hs-TnT, NT-proBNP, Hs-CRP) were measured, and participants were followed for a mean of 9.9 years for mortality outcomes.

Main Results:

  • High Hs-TnT levels were associated with significantly increased mortality from total, CVD, CHD, stroke, cancer, and respiratory causes.
  • Elevated NT-proBNP levels showed strong associations with total, CVD, CHD, and stroke mortality.
  • Increased Hs-CRP levels were linked to higher total, CVD, and respiratory mortality.
  • Simultaneous elevation of multiple biomarkers substantially increased cause-specific mortality risks.

Conclusions:

  • Higher levels of Hs-TnT, NT-proBNP, and Hs-CRP are independently associated with increased risk of death.
  • These associations extend beyond cardiovascular disease to include certain noncardiovascular mortality causes.
  • Combined elevations in these biomarkers indicate a greatly elevated risk for various causes of death.
Abstract

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