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Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor delivery
Xinglu Huang1, Fan Zhang, Hui Wang
1Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, United States.
Biomaterials
|December 12, 2012
Summary
This study developed a novel mesenchymal stem cell (MSC) platform combined with mesoporous silica nanoparticles (MSNs) for targeted glioblastoma delivery and imaging. The engineered MSCs demonstrated effective tumor targeting and multimodal imaging capabilities.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cell Therapy
Background:
- Stem cell engineering offers potential for disease diagnosis and therapy.
- Achieving multifunctionalization in stem cells for combined diagnostic and therapeutic applications remains a challenge.
Purpose of the Study:
- To develop a mesenchymal stem cell (MSC)-based multifunctional platform for targeting orthotopic glioblastoma.
- To integrate tumor-targeted delivery of MSCs with the multimodal imaging capabilities of mesoporous silica nanoparticles (MSNs).
Main Methods:
- Engineered MSCs were combined with MSNs to create a multifunctional platform.
- In vivo multimodal imaging was employed in an orthotopic U87MG glioblastoma model to assess tumor targeting.
- Cellular uptake, particle retention time, and stability were evaluated.
Main Results:
- The MSC-MSN platform demonstrated effective tumor-targeted delivery of MSCs in vivo.
- Higher tumor uptake was observed with the MSC-MSN platform compared to particles without MSCs.
- The platform showed rapid cellular uptake, long retention time, and particle stability.
Conclusions:
- The combination of MSNs and MSCs presents a promising stem cell-based multifunctional platform.
- This approach opens new avenues for multifunctional cell product applications.
- The platform leverages the advantages of both stem cells and nanoparticles for active targeted delivery.
