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[Adipokines in healthy and obese children]

G A Martos-Moreno1, J J Kopchick, J Argente

  • 1Servicios de Pediatría y Endocrinología, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, Madrid, España.

Anales De Pediatria (Barcelona, Spain : 2003)
|December 12, 2012
PubMed

Insights

Childhood obesity is rising, impacting health and economics. Adipokines from fat tissue regulate energy, metabolism, and inflammation, with changes seen in obese children.

Area of Science:

  • Endocrinology
  • Pediatric Metabolism
  • Inflammation Research

Context:

  • Rising global prevalence of childhood and adolescent obesity.
  • Obesity linked to increased comorbidities and premature mortality.
  • Significant economic burden associated with pediatric obesity.

Purpose:

  • To review current knowledge on adipokine dynamics and actions in children.
  • To focus on adipokines' roles in energy homeostasis, metabolic regulation, and inflammation.
  • To highlight differences in adipokine secretion and action between healthy children and those with early-onset obesity.

Summary:

  • Adipose tissue is an endocrine organ secreting various peptides and cytokines known as adipokines.
  • Adipokines play crucial roles in controlling energy balance, carbohydrate metabolism, and inflammatory processes.
  • This review examines adipokine profiles in healthy children (birth to adolescence) and contrasts them with changes observed in early-onset obesity.

Impact:

  • Provides insights into the endocrine function of adipose tissue in pediatric populations.
  • Enhances understanding of metabolic and inflammatory dysregulation in childhood obesity.
  • Informs future research and potential therapeutic strategies for pediatric obesity and its complications.

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