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Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

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Related Experiment Video

Updated: May 16, 2026

Analysis of β-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy
06:27

Analysis of β-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy

Published on: November 30, 2018

β-amyloid dynamics in human plasma.

Yafei Huang, Rachel Potter, Wendy Sigurdson

    Archives of Neurology
    |December 12, 2012
    PubMed
    Summary
    This summary is machine-generated.

    Human plasma beta-amyloid (Aβ) shows daily rhythms that decrease with age but are not affected by amyloidosis. Plasma and cerebrospinal fluid (CSF) Aβ levels did not correlate hourly.

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    Last Updated: May 16, 2026

    Analysis of β-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy
    06:27

    Analysis of β-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy

    Published on: November 30, 2018

    Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
    09:31

    Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

    Published on: March 7, 2019

    Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps
    10:19

    Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps

    Published on: August 14, 2016

    Area of Science:

    • Neurodegenerative diseases
    • Biomarker research
    • Aging research

    Background:

    • Alzheimer's disease is characterized by amyloid-beta (Aβ) plaques.
    • Cerebrospinal fluid (CSF) Aβ is a biomarker, but plasma Aβ dynamics are less understood.
    • Aging and amyloidosis may influence Aβ levels.

    Purpose of the Study:

    • Investigate dynamic changes in human plasma Aβ.
    • Evaluate effects of aging and amyloidosis on plasma Aβ.
    • Correlate plasma Aβ with CSF Aβ concentrations.

    Main Methods:

    • Repeated plasma and CSF sampling in older adults with (Amyloid+) and without (Amyloid-) amyloid deposition, and younger normal controls (YNCs).
    • Hourly plasma Aβ measurements compared across groups.
    • Correlation analysis between plasma and CSF Aβ for linear increase and circadian patterns.

    Main Results:

    • Plasma Aβ exhibited circadian patterns with reduced amplitude in older adults.
    • CSF Aβ showed a linear increase in YNC and Amyloid- groups, but not Amyloid+.
    • No linear increase was observed for plasma Aβ.
    • No significant correlation found between hourly plasma and CSF Aβ concentrations.

    Conclusions:

    • Plasma Aβ displays a circadian rhythm, diminishing with age but independent of amyloid status.
    • No hourly or individual relationship was found between plasma and CSF Aβ levels.
    • Plasma Aβ may not be a reliable direct correlate of CSF Aβ on an hourly basis.