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Related Experiment Video

Updated: May 16, 2026

Psychophysiological Assessment of the Effectiveness of Emotion Regulation Strategies in Childhood
08:09

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Published on: February 11, 2017

Mood dysregulation.

Nina Mikita1, Argyris Stringaris

  • 1Institute of Psychiatry, King's College London, Box P085, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

European Child & Adolescent Psychiatry
|December 12, 2012
PubMed
Summary
This summary is machine-generated.

The DSM-5 nears publication, with ongoing debate on childhood bipolar disorder (BP). Chronic irritability is unlikely a manic presentation, but brief hypomania may be relevant to BP in youth.

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Area of Science:

  • Child and Adolescent Psychiatry
  • Neurobiology
  • Psychiatric Diagnostics

Background:

  • The upcoming DSM-5 publication fuels debate on bipolar disorder (BP) boundaries in youth.
  • Key areas of discussion include chronic irritability and short manic episodes, often grouped under mood dysregulation.
  • Previous reviews and neurobiological evidence are updated.

Purpose of the Study:

  • To review the diagnostic status of chronic irritability and brief hypomania in children and adolescents.
  • To examine neurobiological evidence related to these conditions.
  • To inform future classification and treatment strategies for pediatric mood disorders.

Main Methods:

  • Systematic review of existing literature.
  • Analysis of neurobiological findings.
  • Focus on evidence pertaining to disruptive mood dysregulation disorder and hypomania in youth.

Main Results:

  • Current evidence suggests chronic, severe irritability is not a developmental manifestation of mania.
  • The diagnostic relevance of brief hypomania episodes in pediatric populations remains less clear.
  • Some data supports a potential clinical link between brief hypomania and bipolar disorder in adolescents.

Conclusions:

  • Chronic irritability in youth may not represent a form of pediatric bipolar disorder.
  • Further research is needed to clarify the diagnostic significance of brief hypomanic episodes.
  • Recommendations for future studies aim to refine diagnostic criteria and treatment approaches for mood dysregulation in children and adolescents.