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Incomplete clinical manifestation as a risk factor for coronary artery abnormalities in Kawasaki disease: a

Kee-Soo Ha1, GiYoung Jang, JungHwa Lee

  • 1Department of Pediatrics, Korea University Medical Center Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul, 152-703, Republic of Korea.

European Journal of Pediatrics
|December 12, 2012
PubMed

Insights

Incomplete Kawasaki disease (KD) increases the risk of coronary artery abnormalities (CAAs). This association is stronger in infants under 12 months and in Asian and Indian populations, particularly for cases diagnosed after 2004.

Area of Science:

  • Pediatrics
  • Cardiology
  • Rheumatology

Background:

  • Incomplete Kawasaki disease (KD) presents diagnostic challenges.
  • The link between incomplete KD and coronary artery abnormalities (CAAs) requires clarification.

Purpose of the Study:

  • To determine the risk of CAAs in incomplete KD through a comprehensive meta-analysis.
  • To identify specific risk factors and demographic associations with CAAs in incomplete KD.

Main Methods:

  • Meta-analysis of 20 studies involving 4,504 KD cases and 32,519 controls for CAA risk.
  • Analysis of two studies with 5,390 cases and 37,648 controls for giant aneurysm risk.

Main Results:

  • Incomplete KD is significantly associated with an increased risk of CAAs (OR = 1.447, p = 0.001).
  • Higher risks observed in patients <12 months (OR = 2.023), Asians (OR = 1.57), and Indians (OR = 7.088).
  • Increased association found in studies enrolling patients after 2004 (OR = 1.969).

Conclusions:

  • Incomplete KD is a risk factor for developing CAAs.
  • Younger age (<12 months), Asian, and Indian ethnicities are associated with higher risks.
  • The association appears more pronounced in recent cohorts (post-2004).

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