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Published on: September 8, 2021
In vitro pharmacodynamics of AZD5206 against Staphylococcus aureus
Vincent H Tam1, Kai-Tai Chang, Zhen Yang
1Department of Clinical Sciences and Administration, University of Houston College of Pharmacy, Houston, Texas, USA. vtam@uh.edu
Abstract:
AZD5206 is a novel antimicrobial agent with potent in vitro activity against Staphylococcus aureus. We evaluated the in vitro pharmacodynamics of AZD5206 against a standard wild-type methicillin-susceptible strain (ATCC 29213) and a clinical strain of methicillin-resistant S. aureus (SA62). Overall, bacterial killing against a low baseline inoculum was more remarkable. Low dosing exposures and/or high baseline inoculum resulted in early reduction in bacterial burden, followed by regrowth and selective amplification of the resistant population.
