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Related Experiment Video

Updated: May 16, 2026

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration
13:17

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration

Published on: May 26, 2014

[Microbubbles: current state and future prospects].

Antonio Granata1, Fulvio Floccari, Giuseppe Daidone

  • 1U.O.C. Nefrologia e Dialisi, Ospedale San Giovanni di Dio, Agrigento, Italy. antonio.granata4@tin.it

Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
|December 12, 2012
PubMed
Summary
This summary is machine-generated.

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Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

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Contrast-enhanced ultrasound (CEUS) utilizes advanced microbubbles for imaging and drug delivery. These agents show a high safety profile and diverse therapeutic applications in cancer and diabetes.

Area of Science:

  • Medical imaging
  • Nanotechnology
  • Pharmacology

Context:

  • Contrast-enhanced ultrasound (CEUS) is an advanced application of traditional medical sonography.
  • Ultrasound contrast agents, including first- and second-generation types, utilize various gases within microbubbles.
  • These agents possess a favorable safety profile with minimal hepatic, renal, and central nervous system toxicity.

Purpose:

  • To explore the applications of contrast-enhanced ultrasound (CEUS) in medical imaging and therapeutic delivery.
  • To review the classification and safety of ultrasound contrast agents.
  • To highlight emerging applications of novel ultrasound contrast agents.

Summary:

  • Ultrasound contrast agents are categorized by microbubble gas composition (nitrogen, perfluorocarbon, sulfur hexafluoride), demonstrating excellent safety profiles and low organ toxicity.

Related Experiment Videos

Last Updated: May 16, 2026

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration
13:17

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration

Published on: May 26, 2014

  • CEUS is effective for drug and gene delivery, with novel agents like liposomes, micelles, and perfluorocarbon nanoparticles showing promise.
  • Future applications include treating hypertension, cerebral diseases, various cancers, and type I diabetes via pancreatic islet transplantation.

    • Impact:

    • CEUS offers a safe and effective platform for advanced medical imaging and targeted therapeutic interventions.
    • Novel ultrasound contrast agents are expanding the potential of CEUS in oncology, diabetology, and other critical medical fields.
    • The development of these agents paves the way for innovative drug and gene delivery systems with enhanced efficacy and safety.