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A population-based study to evaluate the effectiveness of multidisciplinary heart failure clinics and identify
Harindra C Wijeysundera1, Gina Trubiani, Xuesong Wang
1Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Ontario, Canada. wijeysundera@gmail.com
Insights
Multidisciplinary heart failure (HF) clinics reduce mortality but increase readmissions in real-world settings. Key features like frequent visits and intensive medication management improve outcomes for HF patients.
Area of Science:
- Cardiology
- Public Health
- Health Services Research
Background:
- Multidisciplinary heart failure (HF) clinics demonstrate efficacy in clinical trials.
- Real-world effectiveness of HF clinics compared to usual care requires further investigation.
- Identifying specific HF clinic features linked to improved patient outcomes is crucial.
Purpose of the Study:
- To compare real-world outcomes of patients with heart failure (HF) treated in specialized HF clinics versus usual therapy.
- To identify specific features of HF clinics that are associated with improved patient outcomes.
- To evaluate the impact of HF clinic intensity and service components on mortality and readmission rates.
Main Methods:
- A population-based study in Ontario, Canada, comparing 1288 patients in HF clinics with 14,468 control patients using propensity-score matching.
- Quantified HF clinic service components (intensity, medication management, visit frequency) using a validated instrument.
- Utilized Cox-proportional hazard models to assess outcomes (mortality, all-cause readmission, HF readmission) and clinic-level characteristics over 4 years.
Main Results:
- HF clinics were associated with a statistically significant decrease in mortality (52.1% vs. 54.7%, P=0.02) but an increase in readmissions (all-cause: 87.4% vs. 86.6%, P=0.009; HF-related: 58.7% vs. 47.3%, P<0.001).
- No significant differences in outcomes were observed between high, medium, or low intensity HF clinics.
- Higher visit frequency (>4 contacts/6 months) and more intensive medication management were independently associated with significantly lower mortality and readmission rates.
Conclusions:
- Multidisciplinary HF clinics are associated with reduced mortality in a real-world setting, despite an increase in readmissions.
- Specific HF clinic characteristics, particularly frequent patient contact and intensive medication management, are key drivers of improved outcomes.
- Optimizing HF clinic models to enhance patient engagement and medication adherence may mitigate readmission risks and further improve survival.
Background:
Multidisciplinary heart failure (HF) clinics are efficacious in clinical trials. Our objectives were to compare real-world outcomes of patients with HF treated in HF clinics versus usual therapy and identify HF clinic features associated with improved outcomes.
Methods And Results:
The service components at all HF clinics in Ontario, Canada, were quantified using a validated instrument and categorized as high/medium/low intensity. We used propensity-scores to match HF clinic and control patients discharged alive after a HF readmission in 2006-2007. Outcomes were mortality, and both all-cause and HF readmission. Cox-proportional hazard models were used to evaluate HF clinic-level characteristics associated with improved outcomes. We identified 14 468 patients with HF, of whom 1288 were seen in HF clinics. Within 4 years of follow-up, 52.1% of patients treated at a HF clinic died versus 54.7% of control patients (P=0.02). Patients treated at HF clinics had increased readmissions (87.4% versus 86.6% for all-cause [P=0.009]; 58.7% versus 47.3% for HF related [P<0.001]). There was no difference between high, medium, or low intensity clinics in terms of mortality, all-cause, or HF readmissions. HF clinics with greater frequency of visits (>4 contacts of significant duration for 6 months) were associated with lower mortality (hazard ratio, 0.14; P<0.0001) and hospitalization (hazard ratio, 0.69; P=0.039). More intensive medication management was associated with lower all-cause (hazard ratio, 0.46; P<0.001) and HF readmission (hazard ratio, 0.42; P<0.001).
Conclusions:
In this real-world population-based study, we found that multidisciplinary HF clinics are associated with a decrease in mortality, but an increase in readmissions.
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