Related Experiment Video

Updated: May 16, 2026

A Task for Assessing the Impact of a Partner on the Speed and Accuracy of Motor Performance in Rats
06:17

A Task for Assessing the Impact of a Partner on the Speed and Accuracy of Motor Performance in Rats

Published on: October 17, 2019

Run-up to participation in ATACH II in Japan

K Toyoda1, S Sato, M Koga

  • 1Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita 565-8565, Japan.

Journal of Vascular and Interventional Neurology
|December 12, 2012
PubMed

Insights

Early intensive blood pressure lowering may benefit acute intracerebral hemorrhage (ICH) patients. The Antihypertensive Treatment for Acute Cerebral Hemorrhage (ATACH) II trial in Japan investigates this for stroke patients.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Clinical Trials

Background:

  • Intracerebral hemorrhage (ICH) is a significant cause of death and disability in Japan.
  • Effective acute antihypertensive strategies for ICH are crucial for improving patient outcomes.

Purpose of the Study:

  • To describe the extensive preparatory work and infrastructure development for the Antihypertensive Treatment for Acute Cerebral Hemorrhage (ATACH) II trial in Japan.
  • To outline the background leading to the initiation of patient registration for this phase III clinical trial.

Main Methods:

  • The report details a multi-step process including a preliminary study, a nationwide survey on antihypertensive treatments for acute ICH, and a multicenter study (SAMURAI-ICH).
  • It also covers the revision of the Japanese drug label for intravenous nicardipine and the establishment of trial infrastructure.

Main Results:

  • The preparatory phase successfully established the necessary framework for launching the ATACH II trial in Japan.
  • This involved collaboration across seventeen Japanese institutions.

Conclusions:

  • The comprehensive groundwork ensures the ATACH II trial can effectively evaluate early intensive systolic blood pressure lowering in acute ICH patients.
  • This rigorous preparation is vital for advancing stroke treatment strategies.

More Related Videos

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram06:12

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram

Published on: March 13, 2018

Reliable Acquisition of Electroencephalography Data during Simultaneous Electroencephalography and Functional MRI11:00

Reliable Acquisition of Electroencephalography Data during Simultaneous Electroencephalography and Functional MRI

Published on: March 19, 2021

Related Concept Videos

Nuclear Power02:36

Nuclear Power

Controlled nuclear fission reactions are used to generate electricity. Any nuclear reactor that produces power via the fission of uranium or plutonium by bombardment with neutrons has six components: nuclear fuel consisting of fissionable material, a nuclear moderator, a neutron source, control rods, reactor coolant, and a shield and containment system.
Nuclear Fuels
Nuclear fuel consists of a fissile isotope, such as uranium-235, which must be present in sufficient quantity to provide a...
International Nursing Organizations II01:28

International Nursing Organizations II

The World Health Organization (WHO) is a specialized agency of the United Nations based in Geneva. The WHO has many initiatives that center around health. Primarily, they lead global efforts to expand universal health coverage using science-based policies and programs. They are also responsible for shaping health research agendas and developing norms and standards.
The WHO provides expert team support, including funding, vaccines, testing, and treatment tools at the country level to fight...
Nuclear Transmutation03:20

Nuclear Transmutation

Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed protons being...
Hybridization of Atomic Orbitals II03:35

Hybridization of Atomic Orbitals II

sp3d and sp3d 2 Hybridization
SBAR II: Application of SBAR01:14

SBAR II: Application of SBAR

SBAR is an effective communication tool used by healthcare professionals to communicate patient information accurately. SBAR stands for Situation, Background, Assessment, and Recommendation. For a better understanding, an example is given below.
SBAR Report from a Nurse to a Health Care Provider
S: "Hello, Dr. Smith. This is Jane, RN, from the Med Surg unit. I am calling to tell you about Ms. White in Room 210, who is experiencing increased pain and redness at her incision site. Her recent...
Nuclear Fusion02:45

Nuclear Fusion

The process of converting very light nuclei into heavier nuclei is also accompanied by the conversion of mass into large amounts of energy, a process called fusion. The principal source of energy in the sun is a net fusion reaction in which four hydrogen nuclei fuse and ultimately produce one helium nucleus and two positrons.
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...